MicroRNA-30a ameliorates hepatic fibrosis by inhibiting Beclin1-mediated autophagy

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MicroRNA‐30a ameliorates hepatic fibrosis by inhibiting Beclin1‐mediated autophagy

We explored the role of microRNA-30a (miR-30a) and the mechanism involved in hepatic fibrosis. MiR-30a overexpression was achieved by miR-30a mimics transfection in hepatic stellate cells (HSCs) (HSC-T6, LX-2), and miR-30a agomir (ago-miR-30a) treatment in mice. MiR-30a levels were measured using TaqMan miRNA assay system, and the localization of miR-30a was detected by fluorescence in situ hyb...

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ژورنال

عنوان ژورنال: Journal of Cellular and Molecular Medicine

سال: 2017

ISSN: 1582-1838

DOI: 10.1111/jcmm.13278